Box 3 - Steps in a typical randomisation process
Sequence generation
- Generate allocation sequence by some random procedure
Allocation concealment
- Develop allocation concealment mechanism (such as numbered, identical bottles or sequentially numbered, sealed, opaque envelopes)
- Prepare the allocation concealment mechanism using the allocation sequence from the sequence generation step
Implementation
- Enrol participants:
- Assess eligibility
- Discuss the trial
- Obtain informed consent
- Enrol participant in trial
- Ascertain intervention assignment (such as opening next envelope)
- Administer intervention
Page last edited: 24 March 2010
