Restricted randomization
Any procedure used with random assignment to achieve balance between study groups in size or baseline characteristics. Blocking is used to ensure that comparison groups will be of approximately the same size.
With stratification, randomization with restriction is carried out separately within each of two or more subsets of participants (for example, defining disease severity or study centers) to ensure that the patient characteristics are closely balanced within each intervention group.
Page last edited: 01 March 2007
